Prognostic value of <i>HMGN</i> family expression in acute myeloid leukemia

نویسندگان

چکیده

Aim: The objective of this work was to investigate the prognostic role HMGN family in acute myeloid leukemia (AML). Methods: A total 155 AML patients with HMGN1–5 expression data from Cancer Genome Atlas database were enrolled study. Results: In chemotherapy-only group, high HMGN2 had significantly longer event-free survival (EFS) and overall (OS) than those low (all p &lt; 0.05), whereas HMGN5 expressers shorter EFS OS 0.05). Multivariate analysis identified that an independent favorable factor for who only received chemotherapy no impact on receiving allogeneic hematopoietic stem cell transplantation. Conclusion: High HMGN2/5 is a potential indicator AML.

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ژورنال

عنوان ژورنال: Future Oncology

سال: 2021

ISSN: ['1744-8301', '1479-6694']

DOI: https://doi.org/10.2217/fon-2020-0555